Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats

Y Chen, L Mu, L Xing, S Li, S Fu - Biological research, 2019 - Springer
… on the apoptosis o renal tubular cells as well as renal fibrosis … using antibodies against Bax,
Bcl-2 and GAPDH (as loading … rhein suppressed interstitial fibrosis as well as apoptosis in a …

The effect of oleuropein on unilateral ureteral obstruction induced-kidney injury in rats: the role of oxidative stress, inflammation and apoptosis

A Kaeidi, A Sahamsizadeh, M Allahtavakoli… - Molecular biology …, 2020 - Springer
… rise in renal tubular pressure [3] and renal vascular … biochemical parameters of apoptosis
(Bax, Bcl-2 and cleaved … Furthermore, oleuropein inhibits oxidative stress and exhibits a …

Anti-apoptotic effect of G-protein-coupled receptor 40 activation on tumor necrosis factor-α-induced injury of rat proximal tubular cells

CS Kim, SY Joo, IJ Kim, HI Choi, EH Bae… - International Journal of …, 2019 - mdpi.com
… in renal tubular apoptosis, a two-week unilateral ureteralapoptotic effects by suppression
of the TNF-α signaling pathway. … the control kidney, and was related to the increased Bax/Bcl-2

Ameliorating effect of troxerutin in unilateral ureteral obstruction induced renal oxidative stress, inflammation, and apoptosis in male rats

A Kaeidi, Z Taghipour, M Allahtavakoli, I Fatemi… - Naunyn-Schmiedeberg's …, 2020 - Springer
… casts in some renal tubules, and “h” indicates renal tubular … that 3 days UUO induces renal
apoptosis via increasing the … the Bcl-2 proteins expression level in the left kidney tissue (Fig. 3)…

Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis

Y Zhang, R Zhang, X Han - Inflammation Research, 2021 - Springer
kidney is stimulated by injury, the intrinsic cells of the kidney (… Crystals deposited in renal
tubules activate NLRP3 … the expression of apoptosis-related proteins Bax, Bcl-2, Cleaved …

Chromatin remodeling factor, INO80, inhibits PMAIP1 in renal tubular cells via exchange of histone variant H2A.Z. for H2A

R Miura, I Mimura, H Saigusa, T Yamazaki… - Scientific Reports, 2023 - nature.com
… decreased in rats with unilateral urethral obstruction. We … PMAIP1 is a member of pro-apoptotic
subfamily of the BCL-2 protein … line 15 and induces apoptosis in lung cancer 16 . PMAIP1 …

[PDF][PDF] Renoprotective effect of direct renin inhibitor (aliskiren) during partial ureteral obstruction

A Elkashef - Journal of Cancer, 2021 - researchgate.net
… that inhibits apoptosis, has been found to be down-regulated in obstructive nephropathy in
rats… proven to inhibit renal tubular cell apoptosis via up-regulation of BCL-2 expression during …

Yiqi Huoxue Tongluo recipe regulates NR4A1 to improve renal mitochondrial function in unilateral ureteral obstruction (UUO) rats

Z He, M Zhang, H Xu, W Zhou, C Xu, Z Wang… - Pharmaceutical …, 2022 - Taylor & Francis
… , and the exploration of renal tubular mitochondrial function in … Also, we detected the
caspase-3 and Bcl-2 in HK2 cells by … expression of anti-apoptotic factor Bcl-2 and a significant …

Exogenous pancreatic kininogenase protects against renal fibrosis in rat model of unilateral ureteral obstruction

J Jin, H Li, J Jin, S Piao, X Shen, Y Wu, J Xu… - Acta pharmacologica …, 2020 - nature.com
… Injured renal tubular cells overexpress chemoattractants that … change was paralleled by
suppression of Bcl-2/Bax and … UUO directly induces renal epithelial cell apoptosis [26] or …

Anti-apoptotic effect of HeidihuangWan in renal tubular epithelial cells via PI3K/Akt/mTOR signaling pathway

YY Li, ZH Tian, SS Su, JJ Shi, C Zhou, LH Zhang… - Journal of …, 2023 - Elsevier
… HDHW inhibits the apoptosis of renal tubular epithelial cells … Special culture medium for rat
renal tubular epithelial cells (CM-… Our results suggest that Bcl-2, Bax, and Caspase3 are all …